Evidence map›Paper›PMID 41752071›Full record

ArticleInternational journal of molecular sciences2026

A Genome-Wide DNA Methylation Survey Reveals Salicylic Acid-Induced Distinct Hypomethylation Linked to Defense Responses Against Biotrophic Pathogens.

Theoni Margaritopoulou, Spyros Foutadakis, Giannis Vatsellas, Martina Samiotaki, Emilia Markellou

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Theoni MargaritopoulouLaboratory of Mycology, Scientific Directorate of Phytopathology, Benaki Phytopathological Institute, 14561 Kifissia, Greece.ORCID 0000-0002-0792-6960
Spyros Foutadakis4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-9161-1605
Giannis Vatsellas4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-1631-1060
Martina SamiotakiProtein Chemistry Facility, Biomedical Sciences Research Center "Alexander Fleming", 16672 Vari, Greece.ORCID 0000-0001-9952-0636
Emilia MarkellouLaboratory of Mycology, Scientific Directorate of Phytopathology, Benaki Phytopathological Institute, 14561 Kifissia, Greece.ORCID 0000-0003-1328-2441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is a conserved regulatory mechanism of gene expression, genome stability, and development, and is highly associated with the effective induction of defense responses for plant priming. In the Green Deal era, the use of plant defense inducers (PDIs), compounds that activate defense and prime plants against imminent pathogen attacks, is a safe and environmentally sustainable approach to support plants against pathogens. Though efforts have succeeded at deciphering part of the mode of action of PDIs, more information is needed to understand the underlying pathways of their effectiveness. Here, salicylic acid (SA), loaded in chitosan nanoparticles, increased hypomethylation by more than 25% for 56 genomic regions that corresponded to defense-related genes, such as pectin lyases, defensins and leucine-rich repeat transmembrane protein kinases against the biotrophic fungal pathogen

Indexed as

DNA MethylationPlant DiseasesSalicylic AcidArabidopsisAscomycotaGene Expression Regulation, PlantGenome, PlantPromoter Regions, GeneticSalicylic Aciddifferentially methylated regionsPodosphaera xanthiiprimingSCF complexubiquitinationwhole-genome bisulfite sequencing (WGBS)

Identifiers

PMID41752071
PMCPMC12940366

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.