Evidence map›Paper›PMID 41751998›Full record

ArticleInternational journal of molecular sciences2026

Discovery of New Antioxidant Molecules Enhancing the Nrf2-Mediated Pathway: Docking Studies and Biological Evaluation.

Simona De Vita, Elena González-Burgos, Stefania Terracciano, Maria Giovanna Chini, María Pilar Gómez-Serranillos, Giuseppe Bifulco

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simona De VitaDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 134, 84084 Fisciano, SA, Italy.ORCID 0000-0002-8203-3580
Elena González-BurgosDepartment of Pharmacology, Pharmacognosy and Botanical, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-2119-8768
Stefania TerraccianoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 134, 84084 Fisciano, SA, Italy.
Maria Giovanna ChiniDepartment of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, IS, Italy.
María Pilar Gómez-SerranillosDepartment of Pharmacology, Pharmacognosy and Botanical, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-9178-3420
Giuseppe BifulcoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 134, 84084 Fisciano, SA, Italy.

Funding

MIUR Italy - PRIN PNRR 2022 P2022CKMPW
6 · The paper itself

Abstract

Oxidative stress has been reported to be implicated in the pathogenesis of many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Enhancing antioxidant response, through the activation of the transcription factor Nrf2, may represent a potential strategy, based on in vitro models. To identify scaffolds potentially able to modulate the Nrf2-Keap1 interaction, docking experiments were carried out using a library of commercially available and in-house synthesized molecules. Compounds

Indexed as

AntioxidantsNF-E2-Related Factor 2Signal TransductionCell Line, TumorHumansKelch-Like ECH-Associated Protein 1Lipid PeroxidationMolecular Docking SimulationOxidative StressReactive Oxygen SpeciesAntioxidantsKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesantioxidantcytoprotectionNrf2 activationoxidative stressSH-SY5Yvirtual screening

Identifiers

PMID41751998
PMCPMC12940199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.