Evidence map›Paper›PMID 41751984›Full record

ArticleInternational journal of molecular sciences2026

Gene Expression Profiling and Prognostic Significance of Nuclear and Membrane Progesterone Receptors in Head and Neck Squamous Cell Carcinoma.

Josipa Jelačić, Nina Milutin, Ilijana Stojković, Ozren Vugrinec, Ana Kvolik Pavić, Sanja Vušković, Ivan Mumlek, Vedran Zubčić, Dinko Leović, Mario Bilić and 1 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Josipa JelačićLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0003-1473-4868
Nina MilutinLaboratory of Molecular Virology and Bacteriology, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-6219-7836
Ilijana StojkovićLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0009-0000-6677-0559
Ozren VugrinecDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Ana Kvolik PavićDepartment of Maxillofacial and Oral Surgery, University Hospital Osijek, 31000 Osijek, Croatia.
Sanja VuškovićDepartment of Oncology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0003-3687-3295
Ivan MumlekBexorg, Inc., New Haven, CT 06419, USA.ORCID 0009-0005-0774-2634
Vedran ZubčićDepartment of Maxillofacial and Oral Surgery, University Hospital Osijek, 31000 Osijek, Croatia.
Dinko LeovićDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Mario BilićDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-2525-9524
Petar OzretićLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID 0000-0001-9757-6636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of developing some types of head and neck squamous cell carcinoma (HNSCC) is seven times higher in males, and such disparities may not be associated only with tobacco and alcohol consumption or HPV infection. Therefore, the endocrine microenvironment is considered another risk factor, as epidemiologic studies have unequivocally shown the protective effect of estrogen in women. This research was focused on progesterone receptors (PRs), the least-studied sex hormone receptors in HNSCC. Our study included fresh tissue samples from 95 primary tumors, 25 metastatic lymph nodes and 40 healthy oral mucosa. Gene expression of nuclear (

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsReceptors, ProgesteroneSquamous Cell Carcinoma of Head and NeckAdultAgedBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMembrane ProteinsMiddle AgedPrognosisBiomarkers, TumorMembrane ProteinsReceptors, Progesteronebiomarkershead and neck squamous cell carcinomamembrane progesterone receptorsprogesterone receptorssex hormone receptors

Identifiers

PMID41751984
PMCPMC12940563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.