Evidence map›Paper›PMID 41751972›Full record

ArticleInternational journal of molecular sciences2026

Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.

Ryosuke Kitoh, Shin-Ya Nishio, Yutaka Takumi, Shin-Ichi Usami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryosuke KitohDepartment of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Nagano, Japan.ORCID 0009-0004-8123-1835
Shin-Ya NishioDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Nagano, Japan.ORCID 0000-0001-6640-2297
Yutaka TakumiDepartment of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Nagano, Japan.
Shin-Ichi UsamiDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Nagano, Japan.ORCID 0000-0002-5068-6122

Funding

Health and Labour Sciences Research Grants for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan 20FC1048Health and Labour Sciences Research Grants for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan 23FC10149Health and Labour Sciences Research Grants for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan H26-Nanchito (Nan)-Ippan-032Health and Labour Sciences Research Grants for Comprehensive Research on Disability Health and Welfare from the Ministry of Health, Labour and Welfare, Japan H29-Nanchito (Nan)-Ippan-031JSPS KAKENHI 21K09580
6 · The paper itself

Abstract

The etiology of idiopathic sudden sensorineural hearing loss (iSSNHL) remains unclear, and genome-wide genetic evidence is limited. We conducted a multicenter Japanese case-control genome-wide association study including 192 clinically defined iSSNHL cases and 15,302 controls aged ≥80 years without a history of hearing loss. After cross-platform SNP harmonization and imputation (Eagle/Minimac4), association testing was performed using dosage-based logistic regression in PLINK 2.0, adjusting for sex and principal components (PC1-PC10). Gene- and pathway-level analyses were conducted using MAGMA and the PANTHER overrepresentation test. Genomic inflation was modest (λ_GC = 1.04). Eight loci reached genome-wide significance (

Indexed as

Genome-Wide Association StudyHearing Loss, SuddenInflammationOxidative StressAged, 80 and overCase-Control StudiesEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansJapanMalePolymorphism, Single Nucleotideconditional analysisgene-based analysisgenome-wide association studyidiopathic sudden sensorineural hearing lossinflammationoxidative stresspathway enrichment

Identifiers

PMID41751972
PMCPMC12941261

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.