Evidence map›Paper›PMID 41751961›Full record

ArticleInternational journal of molecular sciences2026

Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).

Lorena Abreu Fernandes, Youko Nukui, Rosa Maria Marcusso, Michel Elyas Jung Haziot, Augusto César Penalva de Oliveira, Jorge Casseb, Patricia Bianca Clissa, Ana Olivia de Souza, Silas G Villas-Boas, Sabri Saeed Sanabani

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorena Abreu FernandesPostgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, Brazil.
Youko NukuiDepartment of Hematology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0002-7774-4716
Rosa Maria MarcussoDepartment of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.ORCID 0000-0002-8396-0263
Michel Elyas Jung HaziotDepartment of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.ORCID 0000-0002-3549-1992
Augusto César Penalva de OliveiraDepartment of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil.ORCID 0000-0002-4084-7973
Jorge CassebLaboratory of Medical Investigation LIM-56, Department of Dermatology, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0002-4553-2559
Patricia Bianca ClissaImmunopathology Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Ana Olivia de SouzaDevelopment and Innovation Laboratory, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil.ORCID 0000-0001-6025-7500
Silas G Villas-BoasLuxembourg Institute of Science and Technology, 5, Avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-0148-5882
Sabri Saeed SanabaniLaboratory of Medical Investigation LIM-56, Department of Dermatology, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0002-8876-8262

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/09354-9
6 · The paper itself

Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neuroinflammatory disease that lacks noninvasive biomarkers. We used untargeted urine metabolomics with machine learning to profile 113 participants (39 with HAM, 17 with intermediate syndrome, 33 asymptomatic carriers, and 24 healthy controls). Gas chromatography-mass spectrometry identified 175 metabolites, 86 of which showed significant differences (fold change > 2, FDR

Indexed as

BiomarkersHuman T-lymphotropic virus 1Machine LearningMetabolomeMetabolomicsParaparesis, Tropical SpasticAdultFemaleGas Chromatography-Mass SpectrometryHumansMaleMiddle AgedBiomarkersbiomarkersHAM/TSPHTLV-1machine learningmetabolomics

Identifiers

PMID41751961
PMCPMC12940815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.