Evidence map›Paper›PMID 41751955›Full record

ArticleInternational journal of molecular sciences2026

PPAR-Delta Agonist Therapies Did Not Rescue Hallmark Disease Phenotypes in Two Sets of Preclinical Trials in ALS TDP-43 and C9orf72 Model Mice.

David T Luong, Chenchen Niu, Eunice Kim, Nolan Tanji, Ivy Duong, Brandon Galero, Yong-Jie Zhang, Craig L Bennett, Albert R La Spada

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David T LuongDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.ORCID 0009-0008-0880-6160
Chenchen NiuDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.
Eunice KimDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.
Nolan TanjiDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.ORCID 0009-0001-3404-4402
Ivy DuongDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.ORCID 0009-0004-5104-7615
Brandon GaleroDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.ORCID 0009-0004-4610-9404
Yong-Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-9900-4313
Craig L BennettDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-5847-1687
Albert R La SpadaDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA.

Funding

United States Department of Defense W81XWH-20-1-0154
6 · The paper itself

Abstract

Peroxisome-proliferator-activated receptor delta (PPARδ) regulates metabolic, mitochondrial, and inflammatory pathways implicated in neurodegeneration, making it an attractive therapeutic target for amyotrophic lateral sclerosis (ALS). In this study, we evaluated two PPARδ agonists, KD3010 and T3D-959, in two established ALS/FTD mouse models: an AAV-mediated C9orf72 G4C2-repeat expansion model (C9-149R) and the TDP-43

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDNA-Binding ProteinsPPAR deltaAnimalsDisease Models, AnimalHumansMaleMiceMice, TransgenicNeurofilament ProteinsPhenotypeC9orf72 ProteinDNA-Binding Proteinsneurofilament protein LNeurofilament ProteinsPPAR deltaTardbp protein, mouseAAV-149Ramyotrophic lateral sclerosisC9orf72dipeptide repeatKD3010neurofilament light chainPPARδT3D-959TDP-43

Identifiers

PMID41751955
PMCPMC12940718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.