Evidence map›Paper›PMID 41751951›Full record

ArticleInternational journal of molecular sciences2026

Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo.

David Broadley, Alizée Le Riche, Ying Yu, Helene El-Bacha, Hanieh Erdmann, Francisco Jimenez, Mikhail Geyfman, Neil Poloso, Janin Edelkamp, Marta Bertolini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David BroadleyQIMA Life Sciences, QIMA Monasterium GmbH, Mendelstraße 17, 48149 Münster, Germany.
Alizée Le RicheQIMA Life Sciences, QIMA Monasterium GmbH, Mendelstraße 17, 48149 Münster, Germany.
Ying YuAbbVie Inc., Irvine, CA 92612, USA.
Helene El-BachaQIMA Life Sciences, QIMA Monasterium GmbH, Mendelstraße 17, 48149 Münster, Germany.
Hanieh ErdmannPraxis Dr. Pajouh, 22941 Bargteheide, Germany.
Francisco JimenezMediteknia Clinic, 35010 Las Palmas de Gran Canaria, Spain.
Mikhail GeyfmanAbbVie Inc., Irvine, CA 92612, USA.
Neil PolosoAbbVie Inc., Irvine, CA 92612, USA.
Janin EdelkampQIMA Life Sciences, QIMA Monasterium GmbH, Mendelstraße 17, 48149 Münster, Germany.ORCID 0000-0002-2050-3890
Marta BertoliniQIMA Life Sciences, QIMA Monasterium GmbH, Mendelstraße 17, 48149 Münster, Germany.ORCID 0000-0002-5927-6998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting

Indexed as

Hair FollicleIntercellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, AndrogenApoptosisCell ProliferationGene Knockdown TechniquesGene SilencingHairHEK293 CellsHumansMaleRNA, Small InterferingSecreted Frizzled-Related ProteinsAR protein, humanDKK1 protein, humanIntercellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, AndrogenRNA, Small InterferingSecreted Frizzled-Related ProteinsSFRP1 protein, humanandrogen receptorDickkopf 1 (DKK1)male pattern hair lossSecreted frizzled-related protein 1 (SFRP1)Wnt signaling

Identifiers

PMID41751951
PMCPMC12940833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.