ArticleInternational journal of molecular sciences2026
Transcriptomic Profiling Reveals Urokinase-Type Plasminogen Activator-Mediated Regulation of Metabolic Competence and Cumulus Expansion During Mouse Oocyte In Vitro Maturation.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- PLAU accelerates extracellular matrix remodeling through partial epithelial-mesenchymal transition in head and neck squamous cell carcinoma.Translational cancer research · 2026Article
- Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
In vitro maturation (IVM) of mammalian oocytes is an essential fertility option for patients at risk of ovarian hyperstimulation syndrome or needing urgent fertility preservation. However, poor outcomes indicate a limited understanding of the molecular mechanisms behind cumulus cell expansion and extracellular matrix (ECM) remodeling. This study investigated the role of serum-derived urokinase-type plasminogen activator (PLAU) in mouse oocyte IVM. Immature cumulus-oocyte complexes from CD-1 mice were cultured with or without serum, and PLAU activity was blocked using 4-chlorophenylguanidine hydrochloride. Cumulus expansion, oocyte maturation, and cumulus cell transcriptomes were analyzed. Serum supplementation enhanced cumulus expansion and maturation, while absence of serum or PLAU inhibition hindered both processes. External PLAU partially rescued these issues under serum-free conditions. Transcriptome analysis demonstrated that inhibiting PLAU activity reduces the expression of ovulation- and metabolism-related genes, such as those involved in glycolysis and carbohydrate metabolism, while increasing genes related to vesicle-mediated transport. PLAU is crucial for cumulus expansion and metabolic regulation during IVM, affecting ECM remodeling and oocyte quality. Supporting IVM culture media with proteolytic and metabolic factors could improve outcomes in assisted reproduction.
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