Oligodendrocytes Are Active Participants in the Pathogenesis of Multiple Sclerosis and Its Animal Models.

Abstract readReview

In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Min Li LinDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.

Wensheng LinDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4931-7642

Funding

the Department of Defense Multiple Sclerosis Research Program W81XWH-22-1-0757

6 · The paper itself

Abstract

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are autoimmune inflammatory demyelinating diseases of the central nervous system (CNS). For decades, oligodendrocytes were regarded as passive targets of autoimmune inflammation in these conditions. However, recent studies challenge this view, revealing that oligodendrocytes are active participants-not just passive targets-in the pathogenesis of MS and EAE. In this review, we summarize recent research that highlights the active and dynamic roles of oligodendrocytes in these diseases.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisOligodendrogliaAnimalsDisease Models, AnimalHumansMyelin Sheathdemyelinationexperimental autoimmune encephalomyelitisintrinsic oligodendrocyte defectmultiple sclerosismyelinoligodendrocyte

Identifiers

PMID41751916

DOI10.3390/ijms27041779

PMCPMC12941276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.