ArticleInternational journal of molecular sciences2026
Characteristics of C4-Type Zinc Finger Proteins in Tardigrades and Their Responses in Extreme Environments.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The regulatory role of zinc finger proteins is crucial for the development of extreme environmental tolerance in numerous species. Tardigrades, as multicellular animals capable of withstanding multiple extreme conditions, have yet to undergo systematic identification and analysis of their zinc finger proteins. This study first analysed the distribution characteristics of zinc finger proteins across four species of tardigrades. We systematically characterised the family features of C4-type ZFPs in these four species and explored their regulatory roles in extreme environmental adaptation. Statistical genomic investigation reveals a wide distribution of the C4-type ZFP family among tardigrades. Phylogenetically, they separate into six distinct groups, with Group 5 emerging as a functionally specialised branch enriched in stress-responsive promoter elements. Molecular evolutionary evidence points to tandem duplication as key to this branch's expansion and functional innovation, while also highlighting the pervasive purifying selection across this family. Transcriptomic analysis revealed that a specific subset of C4-type ZFP genes belonging to phylogenetic Group 5 in both
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