Evidence map›Paper›PMID 41751868›Full record

ArticleInternational journal of molecular sciences2026

Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Variants in Early-Onset Breast Cancer Among Saudi Women.

Rong Bu, Kaleem Iqbal, Sandeep Kumar Parvathareddy, Saud Azam, Zeeshan Qadri, Eman A Abdul Razzaq, Fouad Al-Dayel, Abdul K Siraj, Khawla S Al-Kuraya

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rong BuGenomic Analytics, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-6853-1049
Kaleem IqbalGenomic Analytics, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0001-5634-5030
Sandeep Kumar ParvathareddyHuman Cancer Genomic Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Saud AzamHuman Cancer Genomic Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-8091-5280
Zeeshan QadriHuman Cancer Genomic Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0003-4026-8987
Eman A Abdul RazzaqTranslational Oncology Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Fouad Al-DayelAnatomic Pathology Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Abdul K SirajTranslational Oncology Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0003-2162-6857
Khawla S Al-KurayaHuman Cancer Genomic Research, Research and Innovation, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-4126-3419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-onset breast cancer (EOBC) is disproportionately common in Saudi Arabia, where women present nearly a decade earlier than in Western countries, suggesting unique inherited susceptibility. While

Indexed as

Breast NeoplasmsExomeGenetic Predisposition to DiseaseGerm-Line MutationAdultAge of OnsetBRCA1 ProteinCase-Control StudiesExome SequencingFemaleGenome-Wide Association StudyHumansMiddle AgedMiddle Eastern PeopleSaudi ArabiaBRCA1 Proteinbreast neoplasmsexome sequencinggenetic predisposition to diseasegerm-line mutationSaudi Arabiayoung adult

Identifiers

PMID41751868
PMCPMC12940663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.