Evidence map›Paper›PMID 41751854›Full record

ReviewInternational journal of molecular sciences2026

Wheat Allergy in the Era of Precision Medicine: From Novel Molecular Markers to New Therapeutic Perspectives.

Solomiya Pukalyak, Weronika Gromek, Aleksandra Tomczak, Ewa Markut-Miotła, Maja Woźniak, Mariusz Wysokiński, Sylwia Smolinska, Emilia Majsiak

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Solomiya PukalyakPolish-Ukrainian Foundation for the Development of Medicine, Nałęczowska 14, 20-701 Lublin, Poland.ORCID 0009-0005-2134-8676
Weronika GromekPolish-Ukrainian Foundation for the Development of Medicine, Nałęczowska 14, 20-701 Lublin, Poland.
Aleksandra TomczakIndependent Public Healthcare Centre of the Ministry of Internal Affairs and Administration in Lublin, Grenadierów 3, 20-331 Lublin, Poland.
Ewa Markut-MiotłaDepartment of Allergology and Paediatry, Medical University of Lublin, Prof. Antoniego Gębali 6, 20-093 Lublin, Poland.
Maja WoźniakPolish-Ukrainian Foundation for the Development of Medicine, Nałęczowska 14, 20-701 Lublin, Poland.ORCID 0009-0009-7400-0170
Mariusz WysokińskiDepartment of Basic Nursing, Faculty of Health Sciences, Medical University of Lublin, Staszica 4/6, 20-081 Lublin, Poland.ORCID 0000-0001-8939-2490
Sylwia SmolinskaDepartment of Clinical Immunology, Faculty of Medicine, Wroclaw Medical University, Parkowa 34, 51-616 Wroclaw, Poland.ORCID 0000-0001-6736-2696
Emilia MajsiakHealth Promotion Department, Faculty of Health Sciences, Medical University of Lublin, Staszica 4/6, 20-081 Lublin, Poland.ORCID 0000-0003-3638-9292

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wheat allergy (WA) poses a diagnostic challenge due to its diverse clinical phenotypes-ranging from classic food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA) to baker's asthma. An additional diagnostic aspect is serological cross-reactivity with grass pollen. Undoubtedly, the transition from extract-based diagnostics to precise component-based diagnostics (CRDs) facilitates the management of wheat allergy. It has significantly improved the diagnostic accuracy for WDEIA ω-5-gliadin (Tri a 19), although considering new knowledge about wheat proteins, it seems necessary to include them in the diagnostic scheme, especially where Tri a 19 remains negative despite clinical symptoms. Therefore, in this review, we evaluate the clinical utility of new wheat molecules with a high risk of anaphylaxis. We pay particular attention to Tri a 37 (

Indexed as

Precision MedicineWheat HypersensitivityAllergensAnaphylaxisAntigens, PlantBiomarkersCross ReactionsGliadinHumansPollenTriticumAllergensAntigens, PlantBiomarkersGliadinanaphylaxiscomponent-resolved diagnostics (CRDs)omalizumabTri a 36 (LMW glutenin)Tri a 37 (alpha-purothionin)wheat allergy

Identifiers

PMID41751854
PMCPMC12940863

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.