Evidence map›Paper›PMID 41751842›Full record

ArticleInternational journal of molecular sciences2026

COPG1 Is a Selectively Essential Regulator of Cancer Progression and Chemoresistance via Redox Modulation and AKT Signaling.

Susmita Sen, Van-Thanh Duong, Youngin Hwang, Seungmi Kim, Euijin Lee, Myoung-Eun Han, Dongjun Lee, Sik Yoon, Sae-Ock Oh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susmita SenDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0003-0652-0341
Van-Thanh DuongDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Youngin HwangDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Seungmi KimDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0009-0007-2036-9584
Euijin LeeDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Myoung-Eun HanDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Dongjun LeeResearch Center for Molecular Control for Cancer Cell Diversity, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0001-6828-401X
Sik YoonDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.ORCID 0000-0002-6449-0761
Sae-Ock OhDepartment of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

Funding

National Research Foundation of Korea (NRF), funded by the Korean government (MSIT) NRF-2022R1A5A2027161 and RS-2023-00223764
6 · The paper itself

Abstract

The coatomer complex has been implicated in cancer progression; however, a comprehensive pan-cancer analysis is lacking. Therefore, it is essential to identify the critical roles and essentiality of coatomer genes across pan-cancer. We systematically profiled the genetic alterations, expression patterns, prognostic relevance, and functional dependencies of all coatomer subunits across multiple cancers using more than 10,000 tumor samples from The Cancer Genome Atlas, complemented by functional perturbation data from CRISPR (n = 1178) and RNAi (n = 707) screens in DepMap. Functional validation was also performed to identify the essentiality of selectively essential coatomer genes in hepatocellular carcinoma (HCC). Gene amplification, most notably of

Indexed as

Coatomer ProteinDrug Resistance, NeoplasmNeoplasmsProto-Oncogene Proteins c-aktSignal TransductionAnimalsCarcinoma, HepatocellularCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMiceOxidation-ReductionCoatomer ProteinProto-Oncogene Proteins c-aktchemoresistancecoatomer complexCOPG1Golgi-ER stresspan-cancer analysisreactive oxygen species (ROS)

Identifiers

PMID41751842
PMCPMC12941082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.