Evidence map›Paper›PMID 41751836›Full record

ArticleInternational journal of molecular sciences2026

High Activity of Hemichannels Permeable to Calcium Ions Leads to ROS Generation and Reduced Cell Viability.

Walter Vásquez, Carolina Urrutia, Ximena López, Luis A Cea, José L Vega, Viviana M Berthoud, Juan C Sáez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Walter VásquezDepartamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.
Carolina UrrutiaDepartamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.
Ximena LópezDepartamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.
Luis A CeaInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia 7500912, Chile.
José L VegaDepartamento de Fisiología, Universidad de Concepción, Concepción 4070409, Chile.ORCID 0000-0001-9333-8729
Viviana M BerthoudDepartment of Pediatrics, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.
Juan C SáezDepartamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago 8320165, Chile.ORCID 0000-0003-3811-0347

Funding

Agencia Nacional de Investigación y Desarrollo 1231523Agencia Nacional de Investigación y Desarrollo ICN2025_026
6 · The paper itself

Abstract

Connexins (Cxs) and pannexin1 (Panx1) form hemichannels (HCs) that enable the exchange of ions and small molecules between the intracellular and extracellular compartments. Since an elevated cytoplasmic Ca

Indexed as

CalciumConnexinsReactive Oxygen SpeciesCell Membrane PermeabilityCell SurvivalConnexin 43Gap Junction beta-1 ProteinGap Junction delta-2 ProteinHeLa CellsHumansHydrogen-Ion ConcentrationNerve Tissue ProteinsCalciumConnexin 43connexin 45ConnexinsGap Junction beta-1 ProteinGap Junction delta-2 ProteinNerve Tissue ProteinsPANX1 protein, humanReactive Oxygen Speciesconnexindye uptakepermeability

Identifiers

PMID41751836
PMCPMC12940605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.