Evidence map›Paper›PMID 41751834›Full record

ArticleInternational journal of molecular sciences2026

Myocardial Matrix Metalloproteinase 3 Protein Expression in Ischemic Heart Failure.

Vitalija Siratavičiūtė, Dalia Pangonytė, Vaiva Lesauskaitė, Lina Utkienė, Lina Jusienė, Jolanta Marcinkevičienė, Milda Kuprytė, Dovydas Gečys, Vaiva Patamsytė, Zita Stanionienė and 1 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vitalija SiratavičiūtėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Dalia PangonytėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Vaiva LesauskaitėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.ORCID 0000-0003-2736-3111
Lina UtkienėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Lina JusienėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Jolanta MarcinkevičienėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Milda KuprytėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Dovydas GečysLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Vaiva PatamsytėLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Zita StanionienėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Reda RadikėLaboratory of Cardiac Pathology, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix metalloproteinase 3 (MMP3), in conjunction with other MMPs, plays a key role in myocardial remodeling by breaking down the extracellular matrix of the heart and the development of heart failure (HF). However, the existing data on MMP3 protein expression in human myocardium remains insufficient. The objective of the present study was to determine the expression of MMP3 protein in left ventricular myocardial cells at varying stages of ischemic HF. To this end, a quantitative and semi-quantitative immunohistochemical analysis was performed on 113 samples of left ventricular myocardium. A non-selective digital myocardial image analysis revealed that the stage A HF group exhibited higher MMP3 protein expression compared to the control group (

Indexed as

Heart FailureMatrix Metalloproteinase 3Myocardial IschemiaMyocardiumAgedFemaleHeart VentriclesHumansImmunohistochemistryMaleMiddle AgedMyocytes, CardiacVentricular RemodelingMatrix Metalloproteinase 3MMP3 protein, humanheart failureimmunohistochemistryischemic heart diseasematrix metalloproteinase 3

Identifiers

PMID41751834
PMCPMC12940760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.