Evidence map›Paper›PMID 41751794›Full record

ArticleInternational journal of molecular sciences2026

Wen Liu, Ananya Gupta, Michael Kerin, Sanjeev Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wen LiuDiscipline of Pathology, Cancer Progression and Treatment Research Group, Lambe Institute for Translational Research, School of Medicine, University of Galway, H91TK33 Galway, Ireland.ORCID 0000-0003-2381-4683
Ananya GuptaDiscipline of Physiology, Human Biology Building, School of Medicine, University of Galway, H91TK33 Galway, Ireland.
Michael KerinDiscipline of Surgery, Lambe Institute for Translational Research, School of Medicine, University of Galway, H91TK33 Galway, Ireland.
Sanjeev GuptaDiscipline of Pathology, Cancer Progression and Treatment Research Group, Lambe Institute for Translational Research, School of Medicine, University of Galway, H91TK33 Galway, Ireland.

Funding

China Scholarship Council 202106370068National Breast Cancer Research Institute FY24001
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) responds to stimuli that disrupts its homeostasis by activating a signalling network known as unfolded protein response (UPR), that restores cellular balance and determines cell fate through three key sensors: inositol-requiring enzyme 1α (IRE1α), activating transcription factor 6 (ATF6), and protein kinase RNA-like ER kinase (PERK). Emerging evidence suggests that UPR regulates the expression of numerous long non-coding RNAs (lncRNAs), which play critical roles in maintaining ER homeostasis. Here we show that expression of lncRNA

Indexed as

eIF-2 KinaseEndoplasmic Reticulum StressRNA, Long NoncodingUnfolded Protein ResponseActivating Transcription Factor 6ApoptosisCell DeathCell Line, TumorEndoribonucleasesGene Expression Regulation, NeoplasticHEK293 CellsHumansProtein Serine-Threonine KinasesSignal TransductionActivating Transcription Factor 6EIF2AK3 protein, humaneIF-2 KinaseEndoribonucleasesH19 long non-coding RNAProtein Serine-Threonine KinasesRNA, Long Noncodingbreast cancercell deathendoplasmic reticulum stressH19long non-coding RNAtriple negative breast cancerunfolded protein response

Identifiers

PMID41751794
PMCPMC12941232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.