Evidence map›Paper›PMID 41751606›Full record

ArticleGenes2026

Cross-Species Exome Sequencing Reveals Recurrent Genomic Alterations in California Sea Lion (

Isabella G Livingston, Catherine F Wise, Allison N Dickey, Rachael Thomas, Alissa C Deming, Barbie Halaska, Frances M D Gulland, Kathleen M Colegrove, Pádraig Duignan, Matthew Breen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isabella G LivingstonDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0003-3951-6525
Catherine F WiseDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0001-6294-0426
Allison N DickeyBioinformatics Research Center, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-7466-2870
Rachael ThomasDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-3029-8798
Alissa C DemingDepartment of Conservation Medicine and Science, Pacific Marine Mammal Center, Laguna Beach, CA 92651, USA.ORCID 0000-0002-3281-5701
Barbie HalaskaThe Marine Mammal Center, Sausalito, CA 94965, USA.
Frances M D GullandThe Marine Mammal Center, Sausalito, CA 94965, USA.ORCID 0000-0002-6416-0156
Kathleen M ColegroveZoological Pathology Program, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Brookfield, IL 61802, USA.
Pádraig DuignanThe Marine Mammal Center, Sausalito, CA 94965, USA.ORCID 0000-0002-6565-4799
Matthew BreenDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0002-8901-4155

Funding

Morris Animal Foundation D10ZO-003
6 · The paper itself

Abstract

BACKGROUND/

objectivesHuman-driven environmental change can promote cancer development in wild species, yet the pathophysiology of wildlife cancers remain largely unexplored. Urogenital carcinoma (UGC) in the California sea lion (CSL) (

methodsWe leveraged the evolutionary conservation between the domestic dog and CSL genomes to perform cross-species whole-exome sequencing (WES) of CSL UGC tumors and matched normal tissue pairs. We also used PCR and Sanger sequencing to investigate the prevalence of DNA from OtHV-1.

resultsBioinformatic analyses identified shared somatic variants and DNA copy number aberrations in UGC tumor samples, including recurrent exonic single-nucleotide variants in

conclusionsThese results demonstrate that cross-species exome capture provides a means to identify genomic alterations that may play a role in the molecular pathogenesis of UGC in the CSL and adds to the body of evidence for an association between OtHV-1 and UGC in this species.

Indexed as

B7-H1 AntigenSea LionsUrogenital NeoplasmsAnimalsExomeFemaleB7-H1 AntigenCalifornia sea lioncomparative genomicscomparative oncologymarine mammalsnon-model organismsPD-1/PD-L1 pathwaysentinel speciesurogenital carcinomawildlife cancer

Identifiers

PMID41751606
PMCPMC12940668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.