Evidence map›Paper›PMID 41751604›Full record

ArticleGenes2026

Deciphering Silence: Functional Studies of GCK Synonymous and Nonsense Variants and Their Importance in Understanding Diabetes.

Concetta Aloi, Alessandro Salina, Serena Cappato, Nicola Minuto, Giuseppe D'Annunzio, Fabio Gotta, Davide Maggi, Paola Mandich, Laura Musso, Renata Bocciardi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Concetta AloiLABSIEM (Laboratory for the Study of Inborn Errors of Metabolism), Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Alessandro SalinaLABSIEM (Laboratory for the Study of Inborn Errors of Metabolism), Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0003-0133-6705
Serena CappatoMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Nicola MinutoRegional Center for Pediatric Diabetes, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-5280-6319
Giuseppe D'AnnunzioRegional Center for Pediatric Diabetes, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0002-1856-2277
Fabio GottaMedical Genetics Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Davide MaggiEndocrinology Unit, Department of Internal Medicine and Medical Specialties, School of Medical and Pharmaceutical Sciences, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-3928-1295
Paola MandichMedical Genetics Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0003-3123-3512
Laura MussoEndocrinology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Renata BocciardiMedical Genetics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Codon, NonsenseDiabetes Mellitus, Type 2GlucokinaseSilent MutationAdultExome SequencingFemaleHumansMaleCodon, NonsenseGlucokinaseGCKminigeneMODY2precision medicinesplicingsynonymous variant

Identifiers

PMID41751604
PMCPMC12941200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.