Evidence map›Paper›PMID 41751596›Full record

SynthesisGenes2026

The Role of

Shahd Abboud, Elizabeth Akam, David John Hunter, Sarabjit Mastana

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shahd AbboudSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.
Elizabeth AkamSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.ORCID 0000-0002-8784-3742
David John HunterSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.ORCID 0000-0003-1060-3334
Sarabjit MastanaSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.ORCID 0000-0002-9553-4886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnterior cruciate ligament (ACL) rupture, Achilles tendinopathy, and stress fracture are common sports injuries with significant long-term effects on performance and health. Despite similar exposure, injury susceptibility varies among athletes, suggesting a genetic component. Variants in

objectiveTo systematically review associations between five selected genes and musculoskeletal injury risk.

methodsFollowing PRISMA 2020 guidelines, PubMed, EMBASE, SPORTDiscus, and Web of Science were searched for studies examining these genes in relation to sports injuries. Data were extracted using Covidence and assessed for quality via the Newcastle-Ottawa Scale (NOS).

resultsTwenty-six studies (n > 7000) were included.

conclusionsGenetic variants in

Indexed as

Anterior Cruciate Ligament InjuriesAthletic InjuriesFractures, StressTendinopathyAchilles TendonActininCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type VGenetic Predisposition to DiseaseGrowth Differentiation Factor 5HumansMatrix Metalloproteinase 3ActininACTN3 protein, humanCOL1A1 protein, humanCOL5A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type VGDF5 protein, humanGrowth Differentiation Factor 5Matrix Metalloproteinase 3MMP3 protein, humanAchilles tendinopathyACL ruptureACTN3COL1A1COL5A1GDF5geneticsMMP3sport injuriesstress fractures

Identifiers

PMID41751596
PMCPMC12940354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.