Evidence map›Paper›PMID 41751590›Full record

ArticleGenes2026

CASP8 and CASP3 mRNA Expression in Autoimmune Lymphoproliferative Syndrome (ALPS) and Chronic Immune Thrombocytopenia (ITP).

Anna Pau, Federico Rondot, Stefano Gambarino, Anna Clemente, Cristina Calvi, Paola Montanari, Ilaria Galliano, Massimiliano Bergallo

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In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna PauImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.ORCID 0009-0002-5430-6008
Federico RondotDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
Stefano GambarinoImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.
Anna ClementeImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.
Cristina CalviImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.
Paola MontanariImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.
Ilaria GallianoImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.ORCID 0000-0002-1273-3178
Massimiliano BergalloImmunopathology Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Piazza Polonia, 94, 10126 Turin, Italy.ORCID 0000-0002-9291-1332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFas/FasL-mediated apoptosis is central to immune homeostasis and is implicated in autoimmune lymphoproliferative syndrome (ALPS) and immune thrombocytopenia (ITP). We aimed to compare whole-blood transcriptional levels of CASP8 and CASP3 across ALPS, chronic ITP, and healthy controls.

methodsCASP8 and CASP3 mRNA expression was quantified by real-time PCR in whole blood from clinically diagnosed ALPS patients, chronic ITP patients, and healthy controls.

resultsCASP8 mRNA expression was significantly increased in ALPS and ITP versus controls (

conclusionsALPS and chronic ITP show distinct CASP8 transcriptional patterns and a shared upregulation of CASP3 at the whole-blood mRNA level. These findings are descriptive and do not directly assess caspase activation or apoptotic pathway activity; further protein- and cell subset-based studies are needed to clarify functional implications.

Indexed as

Autoimmune Lymphoproliferative SyndromeCaspase 3Caspase 8Purpura, Thrombocytopenic, IdiopathicAdultApoptosisCase-Control StudiesChronic DiseaseFemaleHumansMaleRNA, MessengerCASP3 protein, humanCASP8 protein, humanCaspase 3Caspase 8RNA, Messengerapoptosisautoimmune lymphoproliferative syndrome (ALPS)CASP3CASP8immune thrombocytopenia (ITP)lymphocyte homeostasis

Identifiers

PMID41751590
PMCPMC12940764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.