Evidence map›Paper›PMID 41751564›Full record

ReviewGenes2026

Tetralogy of Fallot: Genetic, Epigenetic and Clinical Insights into a Multifactorial Congenital Heart Disease.

Maria Felicia Gagliardi, Emanuele Micaglio, Angelo Micheletti, Sara Benedetti, Diana Gabriela Negura, Francesca Bevilacqua, Giulia Guglielmi, Giulia Pasqualin, Alessandro Giamberti, Massimo Chessa

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Felicia GagliardiFaculty of Medicine and Surgery, Milano-Bicocca University, 20126 Milan, Italy.ORCID 0009-0006-6991-8516
Emanuele MicaglioArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, 20097 Milan, Italy.ORCID 0000-0002-8298-7800
Angelo MichelettiPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Sara BenedettiArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Diana Gabriela NeguraPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Francesca BevilacquaPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.ORCID 0000-0003-2737-8436
Giulia GuglielmiPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Giulia PasqualinPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Alessandro GiambertiCongenital Cardiac Surgery Unit, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Massimo ChessaPediatric and Adult Congenital Heart Centre, IRCCS Policlinico San Donato, 20097 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, classically characterized by right ventricular outflow tract obstruction, ventricular septal defect, overriding aorta, and right ventricular hypertrophy. Recent advances in molecular and genomic research indicate that TOF is part of a phenotypic continuum encompassing Trilogy, Tetralogy, and Pentalogy of Fallot, in which the variability of anatomical presentation reflects shared genetic and epigenetic mechanisms with highly variable penetrance and expressivity. Variants in

Indexed as

Epigenesis, GeneticTetralogy of FallotDNA MethylationHumanscongenital heart diseaseepigeneticsFLT4geneticsgenotype–phenotype correlationNOTCH1precision medicinetetralogy of Fallot

Identifiers

PMID41751564
PMCPMC12940485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.