Evidence map›Paper›PMID 41751540›Full record

ArticleGenes2026

RNAi-Induced Expression of Paternal UBE3A.

Hye Ri Kang, Violeta Zaric, Volodymyr Rybalchenko, Steven J Gray, Ryan K Butler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hye Ri KangDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Violeta ZaricDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Volodymyr RybalchenkoDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-4092-0779
Steven J GrayDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6240-8621
Ryan K ButlerDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5857-6489

Funding

Angelman Syndrome Foundation N/ATaysha Gene Therapies, Inc. N/A
6 · The paper itself

Abstract

BACKGROUND/

objectivesAngelman syndrome is a neurodevelopmental disorder resulting from a deficiency of the maternally inherited

methodsTo induce paternal UBE3A expression, we employed small interfering RNA (siRNA) oligonucleotides (20 mouse candidates and 47 human candidates) and lentiviral short hairpin RNA (LV-shRNA) targeting

resultsFollowing treatment with si

conclusionsshRNA-mediated inhibition of

Indexed as

Angelman SyndromeRNA InterferenceUbiquitin-Protein LigasesAnimalsCells, CulturedGenomic ImprintingHumansInduced Pluripotent Stem CellsMaleMiceNeuronsRNA, Small InterferingRNA, Small InterferingUBE3A protein, humanUbe3a protein, mouseUbiquitin-Protein LigasesAngelman syndromeRNAishRNAUBE3AUBE3A-ATS

Identifiers

PMID41751540
PMCPMC12941255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.