Evidence map›Paper›PMID 41751500›Full record

ArticleCurrent issues in molecular biology2026

Transcriptome and Metabolome Analyses Uncover Genes and Pathways Linking Growth Trajectories to Cardiometabolic Risk Markers in Childhood.

Reena Perchard, Terence Garner, Lucy E Higgins, Philip G Murray, Amirul Roslan, Edward D Johnstone, Adam Stevens, Peter E Clayton

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Reena PerchardDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0002-3072-0055
Terence GarnerDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.
Lucy E HigginsDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0003-0993-497X
Philip G MurrayManchester University NHS Foundation Trust, Manchester M13 9WL, UK.
Amirul RoslanDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.
Edward D JohnstoneDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.
Adam StevensDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.ORCID 0000-0002-1950-7325
Peter E ClaytonDivision of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9WL, UK.

Funding

centre grant to the Maternal and Fetal Health Research Centre by Tommy's The Pregnancy and Baby Charity nilthe Child Growth Foundation nilthe European Research Council nil
6 · The paper itself

Abstract

Small for gestational age (SGA) is often used as a proxy for fetal growth restriction (FGR), yet not all FGR fetuses are born SGA. SGA individuals, particularly those with catch-up growth, have increased cardiometabolic risk. We therefore studied infants and children from pregnancies at increased FGR risk, irrespective of birthweight. Two cohorts enriched for suboptimal fetal growth were recruited: an infant cohort (N = 80) to examine relationships between fetal weight trajectory and postnatal growth and a cohort of children aged 3-7 years (N = 80), 31 of whom provided blood samples for transcriptome and metabolome analyses. In infants, fetal weight trajectory correlated negatively with BMI change from birth to three months (R = -0.40,

Indexed as

cardiometabolic riskfetal growth restrictionmetabolomicstranscriptomics

Identifiers

PMID41751500
PMCPMC12939017

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.