Evidence map›Paper›PMID 41751482›Full record

ArticleCurrent issues in molecular biology2026

Exploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning.

Meijun Liu, Ting Li, Xue Dai, Xueling Liu, Wang Deng

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meijun LiuThe Second Clinical College of Chongqing Medical University, Chongqing 400010, China.
Ting LiThe Second Clinical College of Chongqing Medical University, Chongqing 400010, China.
Xue DaiThe Second Clinical College of Chongqing Medical University, Chongqing 400010, China.
Xueling LiuThe Second Clinical College of Chongqing Medical University, Chongqing 400010, China.
Wang DengThe Second Clinical College of Chongqing Medical University, Chongqing 400010, China.

Funding

the Chongqing Science and Technology Project CSTB2024NSCQ-MSX0125the Joint Project of Chongqing Science and Technology Bureau and Health Commission 2023MSXM091
6 · The paper itself

Abstract

Neohesperidin dihydrochalcone (NHDC) is a synthetic sweetener derived from neohesperidin and can improve pathological changes in sepsis-associated acute lung injury (SALI), but the mechanism by which NHDC inhibits SALI remains unclear. We evaluated the therapeutic effect of NHDC (100 mg/kg) and its potential mechanism using bioinformatics approaches with a Lipopolysaccharide (LPS)-induced SALI model (LPS: 10 mg/kg) in mice (

Indexed as

inflammationmachine learningMAPK pathwayneohesperidin dihydrochalconenetwork pharmacologysepsis-induced acute lung injury

Identifiers

PMID41751482
PMCPMC12939339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.