Evidence map›Paper›PMID 41751472›Full record

ArticleCurrent issues in molecular biology2026

Modulation of Corticotropin-Releasing Hormone Receptor Expression During In Vitro Keratinocyte Differentiation.

Carole-Anne Martins, Sara Lesink, Angéline Roux, Guillaume Collet, Richard Daniellou

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carole-Anne MartinsCosmetology, AgroParisTech, 45100 Orléans, France.ORCID 0009-0009-9872-1706
Sara LesinkUmaï, 111, Boulevard Duhamel du Monceau, 45166 Olivet, France.
Angéline RouxUmaï, 111, Boulevard Duhamel du Monceau, 45166 Olivet, France.
Guillaume ColletCosmetology, AgroParisTech, 45100 Orléans, France.ORCID 0000-0002-0355-563X
Richard DaniellouCosmetology, AgroParisTech, 45100 Orléans, France.ORCID 0000-0001-7296-3736

Funding

Association Nationale de la Recherche et de la Technologie 2023/1716Orleans Metropole 001
6 · The paper itself

Abstract

Corticotropin-releasing hormone (CRH) and its receptors CRHR1 and CRHR2 are major actors in the stress response and are well established as components of the hypothalamic-pituitary-adrenal (HPA) axis. Evidence also suggests they are expressed in peripheral tissues and, more interestingly, in the skin. While CRHR1 expression in keratinocytes is documented in terms of presence or absence, data on CRHR2 remain sparse. Moreover, there is no detailed description of the exact localization of CRHR1/2 receptors within the different layers of the epidermis, leaving this question fully unexplored. To better understand the link between stress and skin disorders, we aimed to investigate the differential expression of CRHR1 and CRHR2 in keratinocytes, depending on their level of differentiation. In vitro results demonstrated that CRHR1 appears to be more abundant at early stages of differentiation and CRHR2 at more advanced stages.

Indexed as

calcium-induced differentiationcorticotropin-releasing hormone receptors (CRHR1/2)keratinocyte differentiationmodulation of expressionskin

Identifiers

PMID41751472
PMCPMC12939058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.