ArticleCurrent issues in molecular biology2026
Association of Serum Creatinine, Urea, and Glomerular Filtration Rate with the Progression of Diabetic Associated Kidney Complications: A Retrospective Case-Control Study.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDiabetes mellitus (DM) is a prevalent metabolic disorder frequently leading to serious renal complications, particularly diabetic nephropathy. This retrospective case-control study investigated the levels and associations of commonly used enzymatic (serum creatinine and urea) and physiological (glomerular filtration rate [GFR]) markers of kidney function in diabetic patients compared to non-diabetic controls. METHODOLOGY: A total of 237 participants were enrolled, comprising 81 diabetic cases and 156 non-diabetic controls. Creatinine and urea levels were determined using enzymatic methods, measuring optical density, whereas GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, based on creatinine, age, and sex. Statistical comparisons include
conclusionsOur findings demonstrate a significant association between diabetes and impaired renal function, as evidenced by elevated creatinine and urea levels and reduced GFR. These readily available biomarkers are crucial prognostic indicators for the early detection and effective management of diabetic nephropathy, emphasizing the importance of rigorous metabolic and blood pressure control to mitigate disease progression.
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