Evidence map›Paper›PMID 41751108›Full record

ArticleAnimals : an open access journal from MDPI2026

Trained Scent Dog Detection and GC-MS Analysis of Volatile Organic Compounds from Murine Coronavirus-Infected Cell Cultures.

Agata Kokocińska-Alexandre, Martyna Woszczyło, Michał Dzięcioł, Agata Kublicka, Adam Szumowski, Jacek Łyczko, Katarzyna Barłowska, Antoni Szumny, Marcin J Skwark, Anna Karolina Matczuk

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agata Kokocińska-AlexandreInstitute of Biological Bases of Animal Production, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID 0000-0001-7329-4802
Martyna WoszczyłoVetAI.bio Ltd., London UB9 5NJ, UK.ORCID 0009-0006-6529-3061
Michał DzięciołDepartment of Reproduction and Clinic for Farm Animals, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-366 Wrocław, Poland.ORCID 0000-0002-5063-4306
Agata KublickaDepartment of Pathology, Division of Microbiology, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0003-2939-5782
Adam SzumowskiDepartment of Food Chemistry and Biocatalysis, The Faculty of Biotechnology, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.
Jacek ŁyczkoDepartment of Food Chemistry and Biocatalysis, The Faculty of Biotechnology, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0002-8423-7296
Katarzyna BarłowskaInstitute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Jastrzębiec, Poland.
Antoni SzumnyDepartment of Food Chemistry and Biocatalysis, The Faculty of Biotechnology, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.
Marcin J SkwarkVetAI.bio Ltd., London UB9 5NJ, UK.
Anna Karolina MatczukDepartment of Pathology, Division of Microbiology, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID 0000-0002-7282-6560

Funding

National Science Centre 2020/39/D/NZ6/03185
6 · The paper itself

Abstract

Volatile organic compounds (VOCs) are increasingly recognized as metabolic byproducts of viral infection and may serve as olfactory cues detectable by trained scent dogs. This study examined whether dogs could distinguish cell culture samples infected with murine hepatitis virus strain 1 (MHV-1), a biosafety level 2 coronavirus model, from uninfected controls. Parallel chemical analysis using gas chromatography-mass spectrometry (GC-MS) identified 14 VOCs in infected and 12 in control samples. Notably, 3-heptanone and 1-nonanol were unique to infected samples, while others such as acetophenone, nonanal, decanal, and benzaldehyde were significantly elevated-often by 1.5 to 3 times-in infected cultures. Two trained dogs demonstrated high detection sensitivity (0.95) for infected samples compared to a previously trained odor cinnamon group (0.88) and responded with shorter latency (

Indexed as

canine olfactioncoronavirusGC-MSmachine learning classifiermurine hepatitis virusscent detection dogsviral infection detectionVOCvolatile organic compounds

Identifiers

PMID41751108
PMCPMC12937300

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.