Evidence map›Paper›PMID 41750921›Full record

ArticleFoods (Basel, Switzerland)2026

Boosting Recombinant Bovine Chymosin in

Xinrun Ren, Xiaoyan Ning, Bo Liu, Xinxin Xu, Lina Men, Angie Deng, Yuhong Zhang, Zhiwei Zhang, Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinrun RenNational Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Xiaoyan NingNational Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Bo LiuNational Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Xinxin XuNational Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.ORCID 0000-0002-4060-4517
Lina MenCollege of Forestry, Shanxi Agricultural University, Jinzhong 030801, China.
Angie DengLucile Packard Children's Hospital at Stanford, Palo Alto, CA 94303, USA.ORCID 0000-0002-3954-6911
Yuhong ZhangNational Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.ORCID 0000-0001-5415-1443
Zhiwei ZhangCollege of Forestry, Shanxi Agricultural University, Jinzhong 030801, China.ORCID 0000-0002-1873-5617
Wei ZhangCollege of Forestry, Shanxi Agricultural University, Jinzhong 030801, China.

Funding

Innovation Program of Chinese Academy of Agricultural Sciences CAAS-BRC-LP-2025-02National Key Research and Development Program of China 2021YFA0910602the National Natural Science Foundation of China NSFC, 32171806
6 · The paper itself

Abstract

Bovine chymosin is key for cheese production, yet its traditional sourcing is unsustainable. While microbial and plant-based alternatives exist, they often cause non-specific proteolysis, leading to bitter flavors in cheese. This study aims to develop a high-yield, methanol-independent platform for recombinant bovine chymosin production by engineering the expression system of

Indexed as

bovine chymosinconstitutive promoter GAPfermentationKomagataella phaffiirecombinant expression

Identifiers

PMID41750921
PMCPMC12939213

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.