Transepithelial Transport of Caffeoylquinic Acids in Caco-2 Cells: Structure Dependence and Modulation by Dietary Flavonoids.

Simin Zhao, Jiao Zhang, Yuting Huang, Yanan Yuan, Ting Wu, Siyi Pan, Xiaoyun Xu

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simin ZhaoCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Jiao ZhangCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Yuting HuangHenan International Joint Laboratory of Tea-Oil Tree Biology and High-Value Utilization, College of Tea and Food Science, Xinyang Normal University, Xinyang 464000, China.

Yanan YuanCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Ting WuCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-2954-1279

Siyi PanCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0001-5017-5536

Xiaoyun XuCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Funding

Hubei Provincial Central Government Guidance Funds for Local Science and Technology Development 2025CSA099Hubei Provincial Technological Innovation Program 2024BBBO29

6 · The paper itself

Abstract

Caffeoylquinic acids (CQAs) are polyphenolic compounds widely present in daily diets, but their bioactivities are limited by poor intestinal absorption, the mechanisms of which remain incompletely understood for various isomers. This study investigated the transepithelial transport of three mono-CQAs and three di-CQAs using Caco-2 monolayers. Concurrently, the potential of five dietary flavonoids to enhance intestinal absorption by modulating efflux transporters was evaluated. Results suggest that CQAs were mainly transported via passive paracellular diffusion. The apparent permeability coefficients (

Indexed as

caffeoylquinic acidsdietary flavonoidsintestinal absorptionP-glycoprotein

Identifiers

PMID41750834

DOI10.3390/foods15040642

PMCPMC12939564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.