ArticleAntioxidants (Basel, Switzerland)2026
Redox-Related Genetic and Biological Ageing Signals in Rapid Pain Progression of Knee Osteoarthritis: A Hypothesis-Generating Analysis in the Osteoarthritis Initiative.
Francisco J Blanco, Natividad Oreiro, Jorge Vázquez-García, Antonio Morano-Torres, Sara Relaño, Laura Martínez-Sotodosos, Diana M Noriega-Cobo, Fátima Otero-Fariña, Alejandro Mosquera, Jose L Fernández and 1 more
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In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Francisco J BlancoGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0000-0001-9821-7635 Natividad OreiroGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.
Jorge Vázquez-GarcíaGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0000-0002-9204-4013 Antonio Morano-TorresGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0009-0003-3968-9490 Sara RelañoGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0009-0007-4522-7347 Laura Martínez-SotodososGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0009-0008-3914-362X Diana M Noriega-CoboGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.
Fátima Otero-FariñaLaboratorio de Genética Molecular y Radiobiología, Centro Oncológico de Galicia, C/Doctor Camilo Veiras, 1, 15009 A Coruña, Spain.
Alejandro MosqueraUnidad de Genética, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), As Xubias, 15006 A Coruña, Spain.
Jose L FernándezLaboratorio de Genética Molecular y Radiobiología, Centro Oncológico de Galicia, C/Doctor Camilo Veiras, 1, 15009 A Coruña, Spain.ORCID 0000-0002-2985-7169 Ignacio Rego-PérezGrupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña (UDC), C/As Xubias de Arriba 84, 15006 A Coruña, Spain.ORCID 0000-0003-1754-1164 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Rapid pain progression in knee osteoarthritis (OA) is heterogeneous and may reflect redox-related mechanisms. We performed an exploratory analysis in Osteoarthritis Initiative (OAI) participants, combining nuclear genome-wide association, mitochondrial DNA (mtDNA) haplogroups, and leukocyte telomere length. Rapid pain progression was defined using the rescaled Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for pain (0-100) within 24-month windows. An additive genome-wide association study (GWAS) in 2946 participants tested 7,762,204 imputed variants, adjusting for age, sex, body mass index (BMI) and three principal components. Haplogroups were analysed in 3357 participants, and telomere length (telomere-to-single-copy gene, T/S, ratio) was analysed in 301 participants. No variant reached genome-wide significance (
Indexed as
genome-wide association studyknee osteoarthritisleukocyte telomere lengthmitochondrial DNA haplogroupsoxidative stresspain trajectoriesrapid pain progressionredox imbalance
Identifiers
PMID41750646
PMCPMC12938837
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