Assessment of Nitric Oxide Release In Vitro via Low-Level Daylight-Equivalent Blue or Red Light Irradiation.

Gareth Hazell, Marina Khazova, Paul O'Mahoney

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gareth HazellUK Health Security Agency, Centre for Radiation, Chemical Climate and Environmental Hazards, Harwell Campus, Chilton, Didcot, Oxford OX11 0RQ, UK.ORCID 0009-0004-2613-9833

Marina KhazovaUK Health Security Agency, Centre for Radiation, Chemical Climate and Environmental Hazards, Harwell Campus, Chilton, Didcot, Oxford OX11 0RQ, UK.

Paul O'MahoneyUK Health Security Agency, Centre for Radiation, Chemical Climate and Environmental Hazards, Harwell Campus, Chilton, Didcot, Oxford OX11 0RQ, UK.ORCID 0000-0003-3221-5105

Funding

the National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Radiation Threats and Hazards NIHR207424

6 · The paper itself

Abstract

Conflicting evidence exists on whether blue or red light modulates nitric oxide (NO) release within skin cells. Using environmentally relevant doses, irradiances and spectral distribution akin to low-level sunlight, we provide evidence that broad-spectrum blue or red (including infrared) light fails to significantly increase NO release in skin cell monolayers compared to unexposed controls for each individual timepoint assessed. We discuss observed discrepancies between our work and recent photobiomodulation (PBM)-based studies presenting measurable upregulation, noting that significant NO induction typically requires high-powered light-emitting diodes (LEDs) or lasers used in clinical settings within a specific narrow spectral band. Thus, while our findings show no significant effect, they provide an important counterpoint for public health discussions on visible light exposure at terrestrial levels, particularly low-level exposures, between 15 and 30 min midday UK visible light exposure.

Indexed as

cardiovascular diseasenitric oxidenitritephotobiomodulationskin

Identifiers

PMID41750612

DOI10.3390/antiox15020232

PMCPMC12938285

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.