TXNIP-Deficiency and Prdx6 Delivery Inhibit Aging/Oxidative Stress-Driven TXNIP-Nlrp3 Inflammasome Activation and Mitigate Pyroptosis in Lens Epithelial Cells.

Bhavana Chhunchha, Eri Kubo, Renuka R Manoharan, Rakesh Kumar, Dhirendra P Singh

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-Antioxidants (Basel, Switzerland) · 2026
Article

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5 · Who and what money

Authors and funding

5 authors.

Bhavana ChhunchhaDepartment of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68186, USA.ORCID 0000-0001-9613-8765

Eri KuboDepartment of Ophthalmology, Kanazawa Medical University, Kanazawa 920-0293, Japan.ORCID 0000-0001-6789-9311

Renuka R ManoharanDepartment of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68186, USA.

Rakesh KumarDepartment of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68186, USA.

Dhirendra P SinghDepartment of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68186, USA.ORCID 0000-0003-3311-2191

Funding

Molecular approach to ameliorate the age-dependent loss of Clock protein Bmal1 and Nrf2-antioxidant response in eye lens: Implications for eye lens health spanR01EY036404 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DHIRENDRA P SINGH · 2025 to 2026

$769k

NEI NIH HHS EY36404NEI NIH HHS R01 EY036404University of Nebraska Medical Center Bridge Grant

6 · The paper itself

Abstract

Deregulated Nlrp3 (NOD-like receptor pyrin 3) inflammasome activation is strongly associated with age-related blinding diseases, including cataract. Previously, we demonstrated that loss of peroxiredoxin6 (Prdx6) promotes reactive oxygen species (ROS) amplification and aberrant activation of Klf9 and Nlrp3 inflammasome activity-driven pyroptosis. In this study, using aging mouse(m)/human(h) lenses and lens epithelial cells (LECs), we reveal a critical link between Nlrp3 and thioredoxin (TRX)-interacting protein (TXNIP), which increases during aging and oxidative stress conditions. We found that aging lenses exhibiting opacity showed elevated ROS levels, increased TXNIP expression, along with upregulation of Nlrp3 inflammasome components, including caspase-1, ASC, IL-1β, IL-18, and gasderminD (GSDMD), with significantly reduced TRX1. mLECs overexpressing TXNIP were more susceptible to hydrogen peroxide (H

Indexed as

agingH2O2Nlrp3oxidative stressPrdx6pyroptosisTXNIPUVB

Identifiers

PMID41750551

DOI10.3390/antiox15020170

PMCPMC12938727

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.