ArticleAntioxidants (Basel, Switzerland)2026
Protective Effect of Resolvin D1, D2, and Their Methyl Esters on Oxidative Stress and Hyaluronidase-Induced Hyaluronic Acid Degradation.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Resolvin E1 promotes the resolution of inflammation and enhances myogenic responses during aged skeletal muscle regeneration.GeroScience · 2026Article
- ORAC: The Method of Choice for Determining Antioxidant Capacity of Food Products?International journal of molecular sciences · 2026Review
- Non-thermal processing of polyphenol- and carotenoid-rich green leafy vegetables for healthy aging: effects on antioxidant properties and bioavailability.Frontiers in nutrition · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hyaluronic acid (HA) injections are commonly employed in the management of osteoarthritis (OA), yet their therapeutic benefits are often limited by oxidative degradation and enzymatic breakdown within the joint. This study investigates whether Resolvin D1, Resolvin D2, and their methyl ester derivatives can enhance the efficacy of HA injections by acting as dual-function agents with both antioxidant and enzyme inhibitory properties. A comprehensive series of in vitro assays-including ORAC, FRAP, DPPH, ABTS, HRS, and SOD-were performed to evaluate antioxidant capacity, using Trolox, Ascorbic acid, β-Carotene, and Quercetin as reference standards. The potential to inhibit HA degradation was assessed through ROS-induced HA fragmentation and hyaluronidase inhibition assay, with epigallocatechin gallate (EGCG) serving as a positive control. The results indicate that Resolvin derivatives, particularly the methyl ester form of Resolvin D1, display mechanism-dependent antioxidant activity, showing pronounced effects in hydrogen atom transfer-based assays (e.g., ORAC and HRS), as well as in ABTS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.