ArticleAntibiotics (Basel, Switzerland)2026
Engineering Industrial Strain of
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
backgroundThe fungus
methodsHere, we applied CRISPR/Cas9 to create a DAOC overproducer in a single step. Our method uses a donor template to simultaneously delete and overexpress genes, offering a simple, efficient, and time-saving solution.
resultsFurthermore, through methodological optimization, the final homozygous multigene-edited strain achieved an industrial-scale DAOC titer of 12.4 ± 0.2 g/L, representing a significant improvement over the initial edited strain (7.2 ± 0.22 g/L).
conclusionsThis demonstrates that CRISPR/Cas9 can effectively edit industrial
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