Evidence map›Paper›PMID 41750466›Full record

ArticleAntibiotics (Basel, Switzerland)2026

Target Fidelity and Failure: Structure-Activity Relationship of High-Molecular-Mass Penicillin-Binding Proteins (HMM-PBPs) in Refractory

Paola Conti, Alberto Pagotto, Sebastiano A Fortuna, Alessandra Giardina, Grete F Privitera, Ester Rosa, Assunta Sartor, Carlo Tascini, Floriana Campanile

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paola ContiDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.ORCID 0009-0001-3574-3694
Alberto PagottoInfectious Diseases Division, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.ORCID 0000-0002-0772-1869
Sebastiano A FortunaDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.
Alessandra GiardinaDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.
Grete F PriviteraBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1807-4780
Ester RosaDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.
Assunta SartorMicrobiology Unit, Udine University Hospital, 33100 Udine, Italy.
Carlo TasciniInfectious Diseases Division, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.ORCID 0000-0001-9625-6024
Floriana CampanileDepartment of Biomedical and Biotechnological Sciences, Section of Microbiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8405-5425

Funding

MUR PNRR Extended Partnership Initiative on Emerging Infectious Diseases PE00000007PIAno di inCEntivi per la RIcerca di Ateneo 2024-2026, PIACERI National ARISE project
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bocillindouble beta-lactamGranulicatella adiacensinfective endocarditisPBP affinitypenicillin-binding proteinspenicillin non-susceptible

Identifiers

PMID41750466
PMCPMC12937247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.