Evidence map›Paper›PMID 41750395›Full record

ArticleBiomolecules2026

Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4

Jia Shi, Ruiting Su, Lili Zhuang, Zhangmei Lin, Xinyuan Ruan, Yichao Qian, Jieying Zhu, Shuyi Wang, Niansheng Yang

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jia ShiDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Ruiting SuDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Lili ZhuangDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Zhangmei LinDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Xinyuan RuanDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Yichao QianInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Jieying ZhuDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Shuyi WangDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Niansheng YangDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Funding

National Natural Science Foundation of China 82171770National Natural Science Foundation of China 82302023National Natural Science Foundation of China 82471818
6 · The paper itself

Abstract

The involvement of the immune system in pulmonary fibrosis is established, the precise contributions of tissue-resident memory T (T

Indexed as

CD4-Positive T-LymphocytesMemory T CellsPulmonary FibrosisReceptors, NotchSignal TransductionAnimalsBleomycinCell DifferentiationHumansLungMaleMiceMice, Inbred C57BLBleomycinReceptors, NotchCD4+ tissue resident memory T cellsNotch signalingpulmonary fibrosis

Identifiers

PMID41750395
PMCPMC12937952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.