Evidence map›Paper›PMID 41750379›Full record

ArticleBiomolecules2026

gga-let-7c-3p Inhibits Chicken Abdominal Adipogenesis by Regulating

Xi Cheng, Shuohan Li, Ke Zhang, Yulong Guo, Hong Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu, Weihua Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xi ChengCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Shuohan LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Ke ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yulong GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Hong LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhuanjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiaojun LiuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Weihua TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Funding

Weihua Tian 32402746；GZC20240431, 2025M770269；252102111031
6 · The paper itself

Abstract

MicroRNAs (miRNAs) have been increasingly involved in mammalian lipid metabolism. However, their regulatory roles and molecular mechanisms in abdominal fat deposition in chicken remain largely unexplored. In this study, based on the previous miRNA transcriptome data during chicken abdominal preadipocytes' adipogenic differentiation, we explored the biological functions and regulatory mechanisms of a differentially expressed miRNA, gga-let-7c-3p, in adipogenesis. Gain- and loss-of-function assays elucidated that gga-let-7c-3p significantly decreased viability, proliferation, cell cycle progression, intracellular lipid droplet accumulation and triglyceride content, as well as the mRNA expression of proliferation- and lipid metabolism-related genes in chicken abdominal preadipocytes. Dual-luciferase reporter assay confirmed that gga-let-7c-3p could directly interact with the 3'UTR of the transcription factor-peroxisome proliferator activated the receptor delta (

Indexed as

Abdominal FatAdipogenesisMicroRNAsAdipocytesAnimalsCell DifferentiationCell ProliferationChickensGene Expression RegulationLipid MetabolismMicroRNAsabdominal fat depositionabdominal preadipocyteschickengga-let-7c-3pPPARD

Identifiers

PMID41750379
PMCPMC12938580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.