Evidence map›Paper›PMID 41750377›Full record

ArticleBiomolecules2026

Transporter-Driven Glycerophosphocholine (GPC) Toxicity Is Conserved from Fission Yeast to Budding Yeast: Roles for Inositol Pyrophosphates and Gde1 Regulation in Fission Yeast.

Victoria Lee Hrach, Beate Schwer, Lane Vitek, Michael Borowicz, Aleksei Innokentev, Ana M Sanchez, Justin R Singer, Stewart Shuman, Jana Patton-Vogt

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria Lee HrachDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0001-6016-2659
Beate SchwerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.ORCID 0000-0002-3824-9819
Lane VitekDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Michael BorowiczDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Aleksei InnokentevMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0009-0007-0407-476X
Ana M SanchezMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-9119-7624
Justin R SingerDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0009-0008-5698-2206
Stewart ShumanMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jana Patton-VogtDepartment of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0003-2189-3664

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Inositol pyrophosphate dynamics affect RNA 3'-processing/transcription terminationR01GM134021 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BEATE SCHWER · 2019 to 2026
$2.8M
National Institute of Health R01-GM134021 to B.S.National Institute of Health R15-GM104876 to J.P.-V.National Institute of Health R35-GM126945 to S.S.NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM134021
6 · The paper itself

Abstract

Glycerophosphocholine (GPC) and glycerophosphoinositol (GPI) are phospholipid metabolites generated by phospholipase-mediated deacylation. In budding yeast, they enter cells via the Git1 permease; in fission yeast, the homolog is Tgp1. This study investigates why GPC is toxic to

Indexed as

GlycerylphosphorylcholineInositol PhosphatesPhosphoric Diester HydrolasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsBiological TransportMultifunctional EnzymesPyrophosphatasesAsp1 protein, S pombeglycerylphosphoinositolGlycerylphosphorylcholineInositol PhosphatesMultifunctional EnzymesPhosphoric Diester HydrolasesPyrophosphatasesSchizosaccharomyces pombe Proteinsglycerophosphocholineinositol pyrophosphateslipid metabolismSaccharomyces cerevisiaeSchizosaccharomyces pombetransport

Identifiers

PMID41750377
PMCPMC12937664

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.