Evidence map›Paper›PMID 41750373›Full record

ArticleBiomolecules2026

Structure-Aided Design of a LuxR-Type Quorum Sensing SuFEx-Based Potential Inhibitor: Covalent or Competitive Inhibition?

Laurent Soulère, Sylvie Reverchon, Jessica Baude, Emmanuel Chefdeville, Antoine Vauchez, Yves Queneau, William Nasser

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laurent SoulèreINSA LYON, CPE Lyon, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Universite de Lyon 1, CNRS, UMR 5246, Bâtiment Lederer, 1 rue Victor Grignard, F-69622 Villeurbanne, France.ORCID 0000-0002-0488-550X
Sylvie ReverchonINSA LYON, Laboratoire Microbiologie, Adaptation et Pathogénie (MAP), Universite de Lyon 1, CNRS, UMR 5240, Bâtiment Pasteur, 11 Avenue Jean Capelle, F-69621 Villeurbanne, France.ORCID 0000-0002-0478-3474
Jessica BaudeINSA LYON, Laboratoire Microbiologie, Adaptation et Pathogénie (MAP), Universite de Lyon 1, CNRS, UMR 5240, Bâtiment Pasteur, 11 Avenue Jean Capelle, F-69621 Villeurbanne, France.
Emmanuel ChefdevilleInstitut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Centre Commun de RMN (CCRMN), Université Claude Bernard Lyon 1, Bâtiment Lederer, 1 rue V. Grignard, F-69622 Villeurbanne, France.
Antoine VauchezInstitut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Centre Commun de la Spectrométrie de Masse (CCSM), Bâtiment Edgar Lederer, 1 rue Victor Grignard, F-69622 Villeurbanne, France.
Yves QueneauINSA LYON, CPE Lyon, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Universite de Lyon 1, CNRS, UMR 5246, Bâtiment Lederer, 1 rue Victor Grignard, F-69622 Villeurbanne, France.ORCID 0000-0003-4052-061X
William NasserINSA LYON, Laboratoire Microbiologie, Adaptation et Pathogénie (MAP), Universite de Lyon 1, CNRS, UMR 5240, Bâtiment Pasteur, 11 Avenue Jean Capelle, F-69621 Villeurbanne, France.ORCID 0000-0001-9848-3597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New

Indexed as

4-ButyrolactoneBacterial ProteinsQuorum SensingRepressor ProteinsTrans-ActivatorsBinding SitesDrug DesignMolecular Docking Simulation4-ButyrolactoneBacterial ProteinsLuxR autoinducer binding proteinsRepressor ProteinsTrans-Activatorsclick chemistryinhibitorLuxRquorum sensingSuFExtyrosine

Identifiers

PMID41750373
PMCPMC12938288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.