Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase.

Artem V Artiukhov, Alexey V Kazantsev, Olga N Solovjeva, Vasily A Aleshin

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Artem V ArtiukhovBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-9858-7564

Alexey V KazantsevFaculty of Chemistry, Lomonosov Moscow State University, 119234 Moscow, Russia.

Olga N SolovjevaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-5530-5934

Vasily A AleshinBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-8984-4821

Funding

Russian Science Foundation 23-74-10036

6 · The paper itself

Abstract

Thiamine (vitamin B1) and its phosphates are essential for almost all organisms. Thiamine diphosphate (ThDP) is the major intracellular derivative which is considered the only form functioning as a coenzyme. Thiamine triphosphate (ThTP), another ubiquitous derivative, lacks a clear physiological function and is usually kept at low levels. However, it can accumulate up to 87% of total thiamine in animal tissues lacking cytosolic thiamine triphosphatase (THTPA) activity. Studies of ThTP coenzyme function have always faced the problem of ThTP hydrolysis to ThDP. To avoid such interference a synthetic stable ThTP analog, bismethylene ThTP (bmThTP), has been synthesized. Given that ThTP accumulation is caused by cytosolic THTPA suppression, cytosolic ThDP-dependent transketolase (TKT) is the primary target for probing (bm)ThTP's coenzyme function. Indeed, bmThTP acts as a TKT coenzyme, with the apparent K

Indexed as

CoenzymesThiamine TriphosphateTransketolaseAnimalsHydrolysisMolecular Docking SimulationThiamine PyrophosphateCoenzymesThiamine PyrophosphateThiamine TriphosphateTransketolasebismethylene thiamine triphosphatecoenzyme dockinghydrolysis-resistant analogthiamine coenzyme functionthiamine diphosphatethiamine triphosphatetransketolasevitamin synthetic analog

Identifiers

PMID41750372

DOI10.3390/biom16020304

PMCPMC12937740

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