Evidence map›Paper›PMID 41750366›Full record

ArticleBiomolecules2026

Leucine Aminopeptidase from

Hualing Li, Qi Hu, Nuo Xu, Xueting Shao, Yuxin Liu, Yuxin Hou, Binjie Wang, Jiye Wang, Jianzhuang Yao, Shurong Hou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hualing LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Qi HuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Nuo XuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Xueting ShaoSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yuxin LiuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yuxin HouSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Binjie WangKey Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China.
Jiye WangKey Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China.
Jianzhuang YaoSchool of Biological Science and Technology, University of Jinan, Jinan 250022, China.ORCID 0000-0002-5017-3677
Shurong HouSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Xiabin ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Funding

Central Guidance on the Development of Local Science and Technology 2025ZY01109Interdisciplinary Research Project of Hangzhou Normal University 2025JCXK02National Natural Science Foundation of China 82073749, 22273032STI2030-Major Projects 2022ZD0214600
6 · The paper itself

Abstract

Heroin is a highly addictive drug that exerts its primary effects through activation of μ-opioid receptors. Its principal active metabolite, 6-monoacetylmorphine (6-MAM), significantly contributes to heroin's neurological effects and acute toxicity. Current pharmacotherapies for heroin use disorder, employing opioid receptor agonist or antagonist, are often limited by risks of dependence, tolerance, and/or adverse side effects. In this context, enzyme-based therapy emerges as a promising alternative by rapidly converting drugs into inactive or less harmful metabolites in the blood. As a macromolecule, the enzyme does not cross the blood-brain barrier, thereby avoiding side effects in CNS. Through structure-based computational screening, Xoo-PepA (PDB ID: 3JRU), a leucine aminopeptidase from

Indexed as

HeroinLeucyl AminopeptidaseXanthomonasBiocatalysisHydrogen-Ion ConcentrationHydrolysisMorphine DerivativesSubstrate SpecificityHeroinLeucyl AminopeptidaseMorphine Derivativesaminopeptidasebiochemical characterizationcatalytic functionheroin abuse

Identifiers

PMID41750366
PMCPMC12937638

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.