In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Di WuWeldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Kazumasa MinamiDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.ORCID 0000-0002-3864-6478 Jing LiuDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA.
Sungsoo NaWeldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA.ORCID 0000-0002-4425-8906 Uma K AryalDepartment of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74075, USA.ORCID 0000-0003-4543-1536 Marxa L FigueiredoInterdisciplinary Biomedical Sciences Program, Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-8134-0749 Alexander G RoblingDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Bai-Yan LiDepartment of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, China.ORCID 0000-0002-1853-0216 Hiroki YokotaWeldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA.ORCID 0000-0002-7881-8959 Funding
Lrp5 signaling in bone mechanotransduction and metabolismR01AR053237 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ALEXANDER G ROBLING, Matthew L Warman · 2005 to 2026
$9.4MDisrupting tumor/bone malignant interactions with multifunctional cytokine sonodeliveryR01CA196947 · NCI · PURDUE UNIVERSITY · PI FIGUEIREDO, MARXA L · 2016 to 2020
$1.9MFacilitating Endogenous Bone Repair in Arthritis with Targeted IL-27 SonodeliveryR01AR069079 · NIAMS · PURDUE UNIVERSITY · PI FIGUEIREDO, MARXA L · 2018 to 2022
$1.7MNational Natural Science Foundation of China 82203641NCI NIH HHS R01CA196947NIAMS NIH HHS R01AR053237NIAMS NIH HHS R01AR069079R&D Program of Beijing Municipal Education Commission KM202310025024
6 · The paper itselfAbstract
Advanced prostate cancer frequently metastasizes to bone, but no effective therapy exists. To seek a novel treatment option and identify a new drug target, we took an induced tumor-suppressing (iTS) cell-based approach and produced tumor-suppressing proteins and conditioned medium (CM). Notably, the overexpression of Lrp5 and β-catenin, as well as the pharmacological Wnt activator, converted osteocytes, Murine mesenchymal stem cells, mononuclear cells, and monocytes into iTS cells. While
Indexed as
Bone NeoplasmsMicrofilament ProteinsProstatic NeoplasmsAnimalsbeta CateninCell Line, TumorCulture Media, ConditionedHumansLow Density Lipoprotein Receptor-Related Protein-5MaleMesenchymal Stem CellsMiceMice, KnockoutOsteocytesbeta CateninCulture Media, ConditionedLow Density Lipoprotein Receptor-Related Protein-5Microfilament ProteinsmoesinboneCD44iTS cellsLrp5MoesinMSCosteocytesprostate cancer
Identifiers
PMID41750310
PMCPMC12938517
What OpenQuestion holds
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