ArticleBiomolecules2026
Thoracic Aortic Aneurysm Development Is Dependent on Membrane Type-1 Matrix Metalloproteinase Activity and Abundance.
Ying Xiong, Rupak Mukherjee, Sarah L Lieser, Adam W Akerman, Robert E Stroud, Elizabeth K Nadeau, Francis G Spinale, John S Ikonomidis, Jeffrey A Jones
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Ying XiongDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Rupak MukherjeeDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0003-4093-2200 Sarah L LieserDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Adam W AkermanDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8117-0591 Robert E StroudDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0009-0000-5969-1924 Elizabeth K NadeauDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Francis G SpinaleDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
John S IkonomidisDepartment of Surgery, Division of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, NC 27599, USA.
Jeffrey A JonesDepartment of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-5133-0427 Funding
COLLAGENASE INHIBITION IN HEART FAILURER01HL059165 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SPINALE, FRANCIS G · 1998 to 2010
$3.2MEndothelin Receptors and Progression to Heart FailureR01HL057952 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SPINALE, FRANCIS G · 1998 to 2011
$3.1MEnhanced Biochemical Monitoring for Aortic Aneurysm DiseaseR01HL169390 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam William Akerman · 2023 to 2026
$2.6MExtracellular Mechanisms For Thoracic Aortic AneurysmsR01HL075488 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI IKONOMIDIS, JOHN S · 2004 to 2008
$1.6MMyocardial Protection and Matrix ProteasesR01HL095608 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SPINALE, FRANCIS G · 2010 to 2013
$1.4MBLRD VA I01 BX000904NHLBI NIH HHS R01 HL057952NHLBI NIH HHS R01 HL059165NHLBI NIH HHS R01 HL075488NHLBI NIH HHS R01 HL095608NHLBI NIH HHS R01 HL169390RRD VA I21 RX001707U.S. Department of Veterans Affairs BLR&D Merit Review Award I01 BX-000904
6 · The paper itselfAbstract
Thoracic aortic aneurysm (TAA) results from dysregulated remodeling of the extracellular matrix mediated by matrix metalloproteinase (MMP) activity. Previous studies identified elevated membrane type-1 MMP (MT1-MMP) abundance and activity during TAA development and suggested aortic fibroblasts as a potential key source. Herein, we extended our understanding of the role of MT1-MMP during TAA development using various MT1-MMP transgenic mouse strains. MT1-MMP deficient (MT1-MMP
Indexed as
Aortic Aneurysm, ThoracicMatrix Metalloproteinase 14AnimalsFibroblastsMiceMice, KnockoutMice, TransgenicMatrix Metalloproteinase 14Mmp14 protein, mousefibroblastmembrane type-1 matrix metalloproteinaseTGF-β neutralizing antibody therapeuticsthoracic aortic aneurysm
Identifiers
PMID41750306
PMCPMC12938681
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