Insights into the Function of a Conserved Cys120 in Human Neuroglobin in Oxidative Stress Regulation of Breast Cancer Cells.

Shu-Qin Gao, Wen Shi, Si-Qi Xia, Zi-Lei He, Ying-Wu Lin

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

N-Acetylcysteine-Functionalized Mixed Micelles Overcome Multiple Intestinal Barriers to Improve Oral Bioavailability and Antioxidant Protection of Imperatorin.Pharmaceutics · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shu-Qin GaoHengyang Medical College, University of South China, Hengyang 421001, China.

Wen ShiDepartment of Laboratory Medicine, Yijishan Hospital of Wannan Medical College, Wuhu 241001, China.

Si-Qi XiaSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.

Zi-Lei HeSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.

Ying-Wu LinHengyang Medical College, University of South China, Hengyang 421001, China.ORCID 0000-0002-2457-0871

Funding

the National Natural Science Foundation of China 32171270the Research Foundation of Education Bureau of Hunan Province, China 23B0400

6 · The paper itself

Abstract

Human neuroglobin (Ngb) is a globin featuring a disulfide bond (Cys46-Cys55) and a redox-active cysteine residue (Cys120) and plays a dual role in cellular stress responses. In this study, we investigated how wild-type (WT) Ngb and its two mutants, C120S Ngb, in which Cys120 is replaced by serine, and A15C Ngb, which contains an engineered Cys15-Cys120 disulfide bridge, modulate oxidative stress in triple-negative breast cancer (MDAMB231) and hormone receptor-positive breast cancer (MCF-7) cells. In both cell lines, WT Ngb enhanced cell survival under H

Indexed as

Breast NeoplasmsCysteineNeuroglobinOxidative StressApoptosisCell Line, TumorCell SurvivalFemaleHumansHydrogen PeroxideMCF-7 CellsMDA-MB-231 CellsOxidation-ReductionReactive Oxygen SpeciesCysteineHydrogen PeroxideNeuroglobinNGB protein, humanReactive Oxygen Speciesapoptosisbreast cancer cellsneuroglobinoxidative stressredox regulation

Identifiers

PMID41750285

DOI10.3390/biom16020215

PMCPMC12938188

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.