Evidence map›Paper›PMID 41750251›Full record

ArticleBiomolecules2026

TrkB Agonist Treatment Decreases Hippocampal Testosterone Contents in a Sex-Dependent Manner Following Neonatal Hypoxia and Ischemia.

Nur Aycan, Irem Isik, Nur Sena Cagatay, Feyza Cetin, Teresita J Valdes-Arciniega, Burak Ozaydin, Sefer Yapici, Robinson W Goy, Luc Collo, Qianqian Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nur AycanDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Irem IsikUniversity College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0009-0008-6652-3927
Nur Sena CagatayDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0002-4040-7580
Feyza CetinDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Teresita J Valdes-ArciniegaDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Burak OzaydinDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0003-4985-160X
Sefer YapiciDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0001-9782-2497
Robinson W GoyWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3636-9515
Luc ColloWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Qianqian ZhaoDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Jens EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Peter FerrazzanoDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Jon E LevineWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Amita KapoorWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
Pelin CengizDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Sex Differences in Neurotrophin Mediated Neonatal Neuroprotection: Role of ER AlphaR01NS111021 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CENGIZ, PELIN · 2019 to 2023
$1.7M
Estrogen receptors and TrkB mediated neuroprotection in neonatal hypoxia-ischemiaK08NS088563 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CENGIZ, PELIN · 2015 to 2019
$994k
Request for triple quadrupole mass spectrometer (LC-MS/MS) for biomarker analysisS10OD028626 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI KAPOOR, AMITA · 2020 to 2020
$313k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NICHD NIH HHS P50 HD105353NIH HHS P51 OD011106NIH HHS S10 OD028626NINDS NIH HHS K08 NS088563NINDS NIH HHS R01 NS111021
6 · The paper itself

Abstract

Hypoxia-ischemia (HI)-related brain injury impacts millions of neonates worldwide. Male neonates are two times more susceptible to developing HI. We have previously reported that the administration of the neurotrophin receptor tyrosine kinase B (TrkB) agonist 7,8-dihydroxyflavone (DHF) following neonatal HI increases hippocampal TrkB phosphorylation and improves hippocampal-dependent learning and memory in early adult life only in females. We hypothesize that sex differences in HI outcomes are due to alterations in neonatal hippocampal steroid content, mainly the neural testosterone. At postnatal day 9,

Indexed as

FlavonesHippocampusHypoxia-Ischemia, BrainReceptor, trkBTestosteroneAnimalsAnimals, NewbornCorticosteroneEstradiolFemaleMaleMiceMice, Inbred C57BLProgesterone6,7-dihydroxyflavoneCorticosteroneEstradiolFlavonesProgesteroneReceptor, trkBTestosteronecorticosteroneestradiolhippocampihypoxia ischemianeonatesprogesteronesex steroidstestosterone

Identifiers

PMID41750251
PMCPMC12938734

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.