Evidence map›Paper›PMID 41750195›Full record

ArticleBrain sciences2026

Higher Purity of Phosphatidylserine Improves Human Cortical Neuron Function by Modulating SIRT1-PGC-1α Pathways.

Sung-Min Jeon, Stanley Cho, Yoon-Seob Lee, Ji-Yu Lee, Eunice J Kang, Tommy D Kim, Jayna Shin, Heejin Jo, Sung-Ung Kang

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In one paragraph

Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sung-Min JeonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Stanley ChoDepartment of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Yoon-Seob LeeDepartment of Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Republic of Korea.
Ji-Yu LeeNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Eunice J KangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Tommy D KimNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Jayna ShinNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Heejin JoNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-4170-945X
Sung-Ung KangNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0002-8393-2588

Funding

Korea Health Technology R&D Project HI22C2064
6 · The paper itself

Abstract

While phosphatidylserine (PS) is recognized for its neuroprotective properties, the effects of PS purity on human cortical neurons remain unexplored. This study investigates the effects of three different PS purities (15 µM of 50%, 70%, and 80%) on neuronal health using human-embryonic-stem-cell-derived cortical neurons. Our findings reveal that higher PS purity enhances the expression of key regulatory proteins Sirtuin 1 (SIRT1) and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), known for their roles in neuroprotection and mitochondrial function. Specifically, 80% PS purity significantly increases SIRT1 and PGC-1α levels, suggesting that PS purity strengthens neuroprotective pathways and improves mitochondrial quality control. Through SIRT1 knockdown experiments, we demonstrate that PS-induced upregulation of PGC-1α is SIRT1 dependent, highlighting a SIRT1-PGC-1α regulatory axis that enhances mitochondrial health. In an amyloid-beta 1-42 (Aβ

Indexed as

agingAβ42-induced Alzheimer’s disease modelbrain healthmitochondrial quality controlphosphatidylserine (PS)PS puritySIRT1-PGC-1α axis

Identifiers

PMID41750195
PMCPMC12938103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.