ArticleBehavioral sciences (Basel, Switzerland)2026
Baseline Mood and "Relational Triad" Predict Acute Qualities of Psychedelic Experience.
Article in Behavioral sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe quality and valence of psychedelic experiences are influenced by a range of psychological and contextual factors. This study examines baseline mood and the "relational triad"-comprising social connectedness, mindfulness, and spirituality-as potential predictors of the quality of naturalistic psychedelic experiences.
methodsData were drawn from the Predicting Responses to Psychedelics dataset, a longitudinal study tracking 654 individuals planning to take a psychedelic substance. Participants completed self-report measures at five time points, before and after ingestion. Baseline mood (depression, anxiety, and wellbeing) and relational triad factors were assessed at Timepoint 1, while acute psychedelic experience quality was measured at Timepoint 3 using validated scales (MEQ-30, CEQ, and ASC).
resultsMystical and challenging experiences were weakly but positively correlated. Baseline depression and anxiety were predictive of more challenging experiences but not of mystical-type experiences, while baseline wellbeing predicted more mystical and less challenging experiences. Mindfulness and spirituality were positively associated with mystical experiences, while social connectedness and mindfulness were inversely associated with challenging experiences.
conclusionsThese findings extend previous research by demonstrating that baseline psychological and relational factors shape the nature of psychedelic experiences.
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