Evidence map›Paper›PMID 41750028›Full record

ReviewBehavioral sciences (Basel, Switzerland)2026

Snake Oil or Panacea? How to Misuse AI in Scientific Inquiries of the Human Mind.

René Schlegelmilch, Lenard Dome

Abstract readReview
In one paragraph

Review in Behavioral sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

René SchlegelmilchDepartment of Psychology, Faculty of Human and Health Sciences, University of Bremen, 28359 Bremen, Germany.ORCID 0000-0003-0285-5291
Lenard DomeDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, University Tübingen, 72074 Tübingen, Germany.ORCID 0000-0001-7487-1974

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large language models (LLMs) are increasingly used to predict human behavior from plain-text descriptions of experimental tasks that range from judging disease severity to consequential medical decisions. While these methods promise quick insights without complex psychological theories, we reveal a critical flaw: they often latch onto accidental patterns in the data that seem predictive but collapse when faced with novel experimental conditions. Testing across multiple behavioral studies, we show these models can generate wildly inaccurate predictions, sometimes even reversing true relationships, when applied beyond their training context. Standard validation techniques miss this flaw, creating false confidence in their reliability. We introduce a simple diagnostic tool to spot these failures and urge researchers to prioritize theoretical grounding over statistical convenience. Without this, LLM-driven behavioral predictions risk being scientifically meaningless, despite impressive initial results.

Indexed as

embedding-based regressionextrapolation failurelarge language modelsmodel adequacyout-of-distribution generalization

Identifiers

PMID41750028
PMCPMC12938490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.