ReviewCancers2026
Elective Neck Dissection Strategies Guided by AJCC-8 Depth-of-Invasion (DOI) in cT1-T2N0 Oral Cavity Cancer-A Systematic Review.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Impact of biopsy-related variables on MRI assessment of tumor invasion in early oral squamous cell carcinoma.Clinical oral investigations · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesClinically node-negative (cN0) neck management in cT1-T2 oral cavity squamous cell carcinoma continues to be a subject of controversy. The eighth edition AJCC has incorporated depth of invasion (DOI) as a significant factor in staging and consideration for possible neck dissection. Establishment of accurate DOI thresholds and their clinical relevance is crucial to maximize oncological outcomes with reduced unnecessary morbidity.
methodsA comprehensive analysis of clinical research assessing elective neck dissection (END) techniques in oral cavity cancers classified by DOI in cT1-T2N0 patients was carried out. The included studies reported occult nodal metastasis rates, overall survival, disease-specific survival, disease-free survival, and regional control.
resultsWith hazard ratios favoring END for overall survival (HR 0.64; 95% CI 0.45-0.92) and disease-free survival (HR 0.45; 95% CI 0.34-0.59), elective neck dissection provided advantages in both survival and regional control. In a national registry, DOI ≥ 5 mm independently raised the risk of nodal failure (HR 2.099; 95% CI 1.346-3.271), while END enhanced neck control in comparison to observation (HR 1.749; 95% CI 1.141-2.680). With ROC-derived cut-offs like 4.59 mm producing positive predictive values for nodal metastasis up to 41.7%, diagnostic thresholds clustered around 4 mm.
conclusionsUnder DOI guidance, elective neck dissection consistently showed oncologic benefit, with practical thresholds convergent around 4 mm for sites in the mixed oral cavity and 3 mm for high-risk subsites. The synthesized results confirmed that DOI is the primary determinant of END when combined with histopathologic and subsite-specific risk factors.
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