Evidence map›Paper›PMID 41749901›Full record

ArticleCancers2026

Repurposing Alkylating Agents in Melanoma via ERCC8 Silencing: A Novel Therapeutic Strategy.

Silvia Filippi, Emma Valeri, Valeria Bartolocci, Elena Paccosi, Diletta Guzzon, Luca Proietti-De-Santis

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Silvia FilippiUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-6213-7350
Emma ValeriUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0009-0004-1570-2707
Valeria BartolocciUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0009-0004-4005-2910
Elena PaccosiUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-5995-8692
Diletta GuzzonUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0009-0006-7391-733X
Luca Proietti-De-SantisUnit of Molecular Genetics of Aging, Department of Ecological and Biological Sciences, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0002-2715-9113

Funding

Ministry of University and Research (MUR) REBALANCE - CUP J53D23003180006
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antisense oligonucleotides (ASOs)chemoresistancecockayne syndrome A proteinDNA damage response (DDR)DNA repair targetingERCC8melanomasynthetic lethality

Identifiers

PMID41749901
PMCPMC12939398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.